2ayp Summary

pdbe.org/2ayp
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Crystal Structure of CHK1 with an Indol Inhibitor

The structure was published by Lin, N.-H., Xia, P., Kovar, P., et al., Zhang, H., Rosenberg, S.H., and Sham, H.L., in 2006 in a paper entitled "Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Serine/threonine-protein kinase Chk1. This molecule has the UniProt identifier O14757 (CHK1_HUMAN)search. The sample contained 269 residues which is < 90% of the natural sequence. Out of 269 residues 268 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase Chk1 O14757 (1-269) (CHK1_HUMAN)search Homo sapienssearch < 90% 269 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14757 (1 - 269) Serine/threonine-protein kinase Chk1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O14757) ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch