2ayl Summary

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2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine Prostaglandin H2 Synthase-1 Complexed With Flurbiprofen

The structure was published by Gupta, K., Selinsky, B.S., and Loll, P.J., in 2006 in a paper entitled "2.0 angstroms structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 1 P05979 (32-584) (PGH1_SHEEP)search Ovis ariessearch 96% 553 100%
B Prostaglandin G/H synthase 1 P05979 (32-584) (PGH1_SHEEP)search Ovis ariessearch 96% 553 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (32 - 584) Prostaglandin G/H synthase 1 Ovis aries

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P05979) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P05979) prostaglandin biosynthetic processsearch oxidation-reduction processsearch regulation of blood pressuresearch response to oxidative stresssearch inflammatory responsesearch cyclooxygenase pathwaysearch fatty acid biosynthetic processsearch prostaglandin metabolic processsearch fatty acid metabolic processsearch lipid metabolic processsearch membranesearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch cytoplasmsearch integral component of membranesearch intracellular membrane-bounded organellesearch organelle membranesearch nucleussearch peroxidase activitysearch heme bindingsearch prostaglandin-endoperoxide synthase activitysearch dioxygenase activitysearch oxidoreductase activitysearch metal ion bindingsearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search