2axa Summary

pdbe.org/2axa
spacer

Crystal Structure Of The Androgen Receptor Ligand Binding Domain In Complex With S-1

The structure was published by Bohl, C.E., Miller, D.D., Chen, J., Bell, C.E., and Dalton, J.T., in 2005 in a paper entitled "Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Androgen receptor. This molecule has the UniProt identifier P10275 (ANDR_HUMAN)search. The sample contained 256 residues which is < 90% of the natural sequence. Out of 256 residues 238 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Androgen receptor P10275 (664-919) (ANDR_HUMAN)search Homo sapienssearch < 90% 256 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10275 (664 - 919) Androgen receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P10275) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch