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Crystal Structure Of The Androgen Receptor Ligand Binding Domain T877A Mutant In Complex With S-1

X-ray diffraction
1.9Å resolution
PDB entry 2ax7 coloured by chain, front view.
PDB entry 2ax7 coloured by chain, side view.
PDB entry 2ax7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Androgen receptor
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Multimeric state: monomeric
Accessible surface area: 11112.65 Å2
Buried surface area: 812.08 Å2
Dissociation area: 406.04 Å2
Dissociation energy (ΔGdiss): -4.73 kcal/mol
Dissociation entropy (TΔSdiss): 4.92 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145222

Macromolecules

Androgen receptor
Chain: A
Length: 256 amino acids
Theoretical weight: 29.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10275 (Residues: 665-920; Coverage: 28%)
Gene names: AR, DHTR, NR3C4
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Androgen receptor in PDB entry 2ax7, assembly 1, front view.
Androgen receptor in PDB entry 2ax7, assembly 1, side view.
Androgen receptor in PDB entry 2ax7, assembly 1, top view.
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