2auh Summary


Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase

The structure was published by Depetris, R.S., Hu, J., Gimpelevich, I., Holt, L.J., Daly, R.J., and Hubbard, S.R., in 2005 in a paper entitled "Structural basis for inhibition of the insulin receptor by the adaptor protein grb14." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Insulin receptor and Growth factor receptor-bound protein 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Insulin receptor P06213 (1005-1310) (INSR_HUMAN)search Homo sapienssearch < 90% 306 98%
B Growth factor receptor-bound protein 14 Q14449 (361-419) (GRB14_HUMAN)search Homo sapienssearch < 90% 59 62%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P06213 (1005 - 1310) Insulin receptor Homo sapiens
Q14449 (361 - 419) Growth factor receptor-bound protein 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch
B BPS (Between PH and SH2)search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P06213) protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ATP bindingsearch transmembrane receptor protein tyrosine kinase activitysearch protein tyrosine kinase activitysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch
B BPS (Between PH and SH2) domainsearch