› 2ats

X-ray diffraction
1.9Å resolution

Dihydrodipicolinate synthase co-crystallised with (S)-lysine

Released:
DOI: 10.2210/pdb2ats/pdb
PDB entry 2ats coloured by chain, front view.
PDB entry 2ats coloured by chain, side view.
PDB entry 2ats coloured by chain, top view.
Source organism: Escherichia coli
Entry authors: Devenish SRA, Dobson RCJ, Jameson GB, Gerrard JA

Function and Biology Details

Reaction catalysed: 
Pyruvate + L-aspartate-4-semialdehyde = (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141376 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
4-hydroxy-tetrahydrodipicolinate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 292 amino acids
Theoretical weight: 31.3 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A6L2 (Residues: 1-292; Coverage: 100%)
Gene names: JW2463, b2478, dapA
Sequence domains: Dihydrodipicolinate synthetase family
Structure domains: Aldolase class I

Ligands and Environments

3 bound ligands:
Ligand K 2 x K
Ligand CL 2 x CL
Ligand DLY 3 x DLY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3121
Unit cell:
a: 121.68Å b: 121.68Å c: 109.799Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.169 0.168 0.202
Expression system: Escherichia coli

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