Structure analysis

Crystal structure of the Skp1-Skp2-Cks1 complex

X-ray diffraction
3Å resolution
Source organism: Homo sapiens
Assemblies composition:
hetero trimer (preferred)
hetero hexamer
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 24876.76 Å2
Buried surface area: 5959.75 Å2
Dissociation area: 1,493.5 Å2
Dissociation energy (ΔGdiss): 18.55 kcal/mol
Dissociation entropy (TΔSdiss): 12.74 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158185
Assembly 2
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Multimeric state: hetero hexamer
Accessible surface area: 48640.59 Å2
Buried surface area: 13052.34 Å2
Dissociation area: 564.37 Å2
Dissociation energy (ΔGdiss): 1.98 kcal/mol
Dissociation entropy (TΔSdiss): 14.74 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158187
Assembly 3
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Multimeric state: hetero hexamer
Accessible surface area: 50239.93 Å2
Buried surface area: 11454.83 Å2
Dissociation area: 564.37 Å2
Dissociation energy (ΔGdiss): 1.95 kcal/mol
Dissociation entropy (TΔSdiss): 14.76 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158187

Macromolecules

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Chain: B
Length: 336 amino acids
Theoretical weight: 37.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13309 (Residues: 89-424; Coverage: 79%)
Gene names: FBXL1, SKP2
Pfam: F-box-like
InterPro:
CATH: Ribonuclease Inhibitor
SCOP:

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Chain: C
Length: 69 amino acids
Theoretical weight: 8.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61024 (Residues: 5-73; Coverage: 87%)
Gene names: CKS1, CKS1B, PNAS-143, PNAS-16
Pfam: Cyclin-dependent kinase regulatory subunit
InterPro:
CATH: Cyclin-dependent kinase, regulatory subunit
SCOP: Cell cycle regulatory proteins

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