2aoa Summary

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Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain

The structure was published by Phan, J., Shi, Z.D., Burke, T.R., and Waugh, D.S., in 2005 in a paper entitled "Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.99 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Growth factor receptor-bound protein 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Growth factor receptor-bound protein 2 P62993 (55-153) (GRB2_HUMAN)search Homo sapienssearch 100% 99 93%
B Growth factor receptor-bound protein 2 P62993 (55-153) (GRB2_HUMAN)search Homo sapienssearch 100% 99 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62993 (55 - 153) Growth factor receptor-bound protein 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P62993) SH2 domainsearch SHC Adaptor Proteinsearch PF00017: SH2 domainsearch
Chain InterPro annotation
A, B SH2 domainsearch