2alr Summary

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PDB entry 2alr (supersedes 1alr)

ALDEHYDE REDUCTASE

The structure was published by El-Kabbani, O., Green, N.C., Lin, G., et al., Moore, K.M., Flynn, T.G., and DeLucas, L.J., in 1994 in a paper entitled "Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.48 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ALDEHYDE REDUCTASE. This molecule has the UniProt identifier P14550 (AK1A1_HUMAN)search. The sample contained 324 residues which is 100% of the natural sequence. Out of 324 residues 312 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ALDEHYDE REDUCTASE P14550 (2-325) (AK1A1_HUMAN)search Homo sapienssearch 100% 324 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P14550 (2 - 325) ALDEHYDE REDUCTASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P14550) Aldo-keto reductases (NADP)search NADP-dependent oxidoreductasesearch PF00248: Aldo/keto reductase familysearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P14550) oxidation-reduction processsearch aldehyde catabolic processsearch L-ascorbic acid biosynthetic processsearch glucose metabolic processsearch D-glucuronate catabolic processsearch cellular aldehyde metabolic processsearch cytosolsearch apical plasma membranesearch extracellular vesicular exosomesearch extracellular spacesearch oxidoreductase activitysearch L-glucuronate reductase activitysearch alditol:NADP+ 1-oxidoreductase activitysearch electron carrier activitysearch alcohol dehydrogenase (NADP+) activitysearch

Chain InterPro annotation
A Aldo/keto reductasesearch Aldo/keto reductase, conserved sitesearch Aldo/keto reductase subgroupsearch NADP-dependent oxidoreductase domainsearch