2ak5 Summary

pdbe.org/2ak5
spacer

beta PIX-SH3 complexed with a Cbl-b peptide

The structure was published by Jozic, D., Cardenes, N., Deribe, Y.L., et al., Dikic, I., Rittinger, K., and Bravo, J., in 2005 in a paper entitled "Cbl promotes clustering of endocytic adaptor proteins." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Rho guanine nucleotide exchange factor 7 and 8-residue peptide from a signal transduction protein CBL-B.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Rho guanine nucleotide exchange factor 7 O55043 (5-66) (ARHG7_RAT)search Rattus norvegicussearch < 90% 64 100%
B Rho guanine nucleotide exchange factor 7 O55043 (5-66) (ARHG7_RAT)search Rattus norvegicussearch < 90% 64 100%
D 8-residue peptide from a signal transduction protein CBL-B Q13191 (904-911) (CBLB_HUMAN)search Homo sapienssearch < 90% 8 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
O55043 (5 - 66) Rho guanine nucleotide exchange factor 7 Rattus norvegicus
Q13191 (904 - 911) 8-residue peptide from a signal transduction protein CBL-B

Chain Structural classification (CATH) Sequence family (Pfam)
A, B SH3 Domainssearch Variant SH3 domainsearch
D
Chain InterPro annotation
A, B SH3 domainsearch Variant SH3 domainsearch
D