2aiy Summary

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R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 20 STRUCTURES

The structure was published by O'Donoghue, S.I., Chang, X., Abseher, R., Nilges, M., and Led, J.J., in 2000 in a paper entitled "Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (INSULIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (INSULIN) P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
C PROTEIN (INSULIN) P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
E PROTEIN (INSULIN) P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
G PROTEIN (INSULIN) P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
I PROTEIN (INSULIN) P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
K PROTEIN (INSULIN) P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
B PROTEIN (INSULIN) P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%
D PROTEIN (INSULIN) P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%
F PROTEIN (INSULIN) P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%
H PROTEIN (INSULIN) P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%
J PROTEIN (INSULIN) P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%
L PROTEIN (INSULIN) P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01308 (90 - 110) PROTEIN (INSULIN)

Chain Structural classification (SCOP) Sequence family (Pfam)
A, C, E, G, I, K (P01308) Insulin-likesearch PF00049: Insulin/IGF/Relaxin familysearch
B, D, F, H, J, L (P01308) Insulin-likesearch PF00049: Insulin/IGF/Relaxin familysearch
Chain InterPro annotation
A, C, E, G, I, K Insulin-likesearch Insulin, conserved sitesearch
B, D, F, H, J, L Insulinsearch Insulin-likesearch