› 2aia

X-ray diffraction
1.7Å resolution

S.pneumoniae PDF complexed with SB-543668

Released:
DOI: 10.2210/pdb2aia/pdb
PDB entry 2aia coloured by chain, front view.
PDB entry 2aia coloured by chain, side view.
PDB entry 2aia coloured by chain, top view.
Source organism: Streptococcus pneumoniae
Primary publication:
Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species.
Smith KJ, Petit CM, Aubart K, Smyth M, McManus E, Jones J, Fosberry A, Lewis C, Lonetto M, Christensen SB
Protein Sci 12 349-60 (2003)
PMID: 12538898

Function and Biology Details

Reaction catalysed: 
Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184127 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptide deformylase Chain: A
Molecule details ›
Chain: A
Length: 203 amino acids
Theoretical weight: 22.68 KDa
Source organism: Streptococcus pneumoniae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8DP79 (Residues: 1-203; Coverage: 100%)
Gene names: def, spr1310
Sequence domains: Polypeptide deformylase
Structure domains: Peptide deformylase

Ligands and Environments

3 bound ligands:
Ligand NI 1 x NI
Ligand SO4 1 x SO4
Ligand SB8 1 x SB8
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43
Unit cell:
a: 49.701Å b: 49.701Å c: 91.835Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.235 0.268
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Impact of the N-terminal amino acid on targeted protein degradation.
Meinnel et al. (2006)
2 more

2 mentions without citation

Substrate and docking interactions in serine/threonine protein kinases.
Goldsmith et al. (2007)
1 more