2ags Summary


Trypanosoma rangeli Sialidase in Complex with 2-Keto-3-deoxy-D-glycero-D-galacto-2,3-difluoro-nononic acid (2,3-difluoro-KDN)

The structure was published by Watts, A.G., Oppezzo, P., Withers, S.G., Alzari, P.M., and Buschiazzo, A., in 2006 in a paper entitled "Structural and Kinetic Analysis of Two Covalent Sialosyl-Enzyme Intermediates on Trypanosoma rangeli Sialidase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of sialidase. This molecule has the UniProt identifier O44049 (O44049_TRYRA)search. The sample contained 652 residues which is 100% of the natural sequence. Out of 652 residues 632 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A sialidase O44049 (23-660) (O44049_TRYRA)search Trypanosoma rangelisearch 100% 652 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O44049 (23 - 660) sialidase Trypanosoma rangeli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (O44049) Trypanosoma sialidase, C-terminal domainsearch, Sialidases (neuraminidases)search Neuraminidasesearch, Jelly Rollssearch PF13385: Concanavalin A-like lectin/glucanases superfamilysearch

Chain ID Molecular function (GO) Biological process (GO)
A (O44049) exo-alpha-sialidase activitysearch exo-alpha-(2->3)-sialidase activitysearch hydrolase activity, acting on glycosyl bondssearch hydrolase activitysearch exo-alpha-(2->6)-sialidase activitysearch exo-alpha-(2->8)-sialidase activitysearch metabolic processsearch pathogenesissearch

Chain InterPro annotation
A Trypanosome sialidasesearch Sialidasessearch Concanavalin A-like lectin/glucanase domainsearch Sialidase familysearch