2aeq Summary

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An epidemiologically significant epitope of a 1998 influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex.

The structure was published by Venkatramani, L., Bochkareva, E., Lee, J.T., et al., Laver, W.G., Bochkarev, A., and Air, G.M., in 2006 in a paper entitled "An Epidemiologically Significant Epitope of a 1998 Human Influenza Virus Neuraminidase Forms a Highly Hydrated Interface in the NA-Antibody Complex" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely neuraminidase, FAB light chain, and FAB heavy chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A neuraminidase Q80DL0 (75-469) (Q80DL0_9INFA)search Influenza A virus (A/Memphis/31/98(H3N2))search < 90% 395 98%
L FAB light chain Not available
Mus musculussearch Not available 214 50%
H FAB heavy chain P84751 (1-217) (HVM63_MOUSE)search Mus musculussearch 92% 217 53%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q80DL0 (75 - 469) neuraminidase Influenza A virus
P84751 (1 - 217) FAB heavy chain Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Sialidases (neuraminidases)search Neuraminidasesearch Neuraminidasesearch
L Immunoglobulinssearch
H (P84751) Immunoglobulinssearch PF07654: Immunoglobulin C1-set domainsearch, PF07686: Immunoglobulin V-set domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q80DL0) carbohydrate metabolic processsearch virion membranesearch membranesearch host cell membranesearch exo-alpha-sialidase activitysearch
H (P84751) extracellular regionsearch antigen bindingsearch

Chain InterPro annotation
A Glycoside hydrolase, family 34search Sialidasessearch
L Immunoglobulin/major histocompatibility complex, conserved sitesearch search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
H search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch