2adm Summary


PDB entry 2adm (supersedes 1adm)


The structure was published by Schluckebier, G., Kozak, M., Bleimling, N., Weinhold, E., and Saenger, W., in 1997 in a paper entitled "Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of ADENINE-N6-DNA-METHYLTRANSFERASE TAQI.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ADENINE-N6-DNA-METHYLTRANSFERASE TAQI P14385 (1-421) (MTTA_THEAQ)search Thermus aquaticussearch 93% 421 91%
B ADENINE-N6-DNA-METHYLTRANSFERASE TAQI P14385 (1-421) (MTTA_THEAQ)search Thermus aquaticussearch 93% 421 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P14385 (1 - 421) ADENINE-N6-DNA-METHYLTRANSFERASE TAQI Thermus aquaticus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P14385) DNA methylase TaqI, N-terminal domainsearch, TaqI C-terminal domain-likesearch Vaccinia Virus protein VP39search, Adenine-n6-DNA-methyltransferase Taqi, Chain A, domain 2search PF12950: TaqI-like C-terminal specificity domainsearch, PF13659: Methyltransferase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P14385) nucleic acid bindingsearch site-specific DNA-methyltransferase (adenine-specific) activitysearch methyltransferase activitysearch transferase activitysearch DNA restriction-modification systemsearch methylationsearch DNA methylation on adeninesearch

Chain InterPro annotation
A, B DNA methylase, N-6 adenine-specific, conserved sitesearch N6 adenine-specific DNA methyltransferase, N12 classsearch N6 adenine-specific DNA methyltransferase, TaqI classsearch N6 adenine-specific DNA methyltransferase, TaqI class, C-terminalsearch TaqI-like C-terminal specificity domainsearch S-adenosyl-L-methionine-dependent methyltransferasesearch