2acx Summary


Crystal Structure of G protein coupled receptor kinase 6 bound to AMPPNP

The structure was published by Lodowski, D.T., Tesmer, V.M., Benovic, J.L., and Tesmer, J.J., in 2006 in a paper entitled "The Structure of G Protein-coupled Receptor Kinase (GRK)-6 Defines a Second Lineage of GRKs." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of G protein-coupled receptor kinase 6.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A G protein-coupled receptor kinase 6 P43250 (1-576) (GRK6_HUMAN)search Homo sapienssearch 100% 576 85%
B G protein-coupled receptor kinase 6 P43250 (1-576) (GRK6_HUMAN)search Homo sapienssearch 100% 576 85%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P43250 (1 - 576) G protein-coupled receptor kinase 6 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P43250) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch, PF00615: Regulator of G protein signaling domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P43250) membranesearch protein bindingsearch protein kinase activitysearch ATP bindingsearch G-protein coupled receptor kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch kinase activitysearch regulation of G-protein coupled receptor protein signaling pathwaysearch protein phosphorylationsearch termination of G-protein coupled receptor signaling pathwaysearch signal transductionsearch phosphorylationsearch Wnt signaling pathwaysearch

Chain InterPro annotation
A, B GPCR kinasesearch Regulator of G protein signalling domainsearch Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Regulator of G protein signalling superfamilysearch Protein kinase, ATP binding sitesearch