2ac3 Summary


Structure of human Mnk2 Kinase Domain

The structure was published by Jauch, R., Jakel, S., Netter, C., et al., Aicher, B., Jackle, H., and Wahl, M.C., in 2005 in a paper entitled "Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of MAP kinase-interacting serine/threonine kinase 2. This molecule has the UniProt identifier Q9HBH9 (MKNK2_HUMAN)search. The sample contained 316 residues which is < 90% of the natural sequence. Out of 316 residues 277 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MAP kinase-interacting serine/threonine kinase 2 Q9HBH9 (72-385) (MKNK2_HUMAN)search Homo sapienssearch < 90% 316 87%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9HBH9 (72 - 385) MAP kinase-interacting serine/threonine kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q9HBH9) protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch