2abl Summary



The structure was published by Nam, H.J., Haser, W.G., Roberts, T.M., and Frederick, C.A., in 1996 in a paper entitled "Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ABL TYROSINE KINASE. This molecule has the UniProt identifier P00519 (ABL1_HUMAN)search. The sample contained 163 residues which is < 90% of the natural sequence. Out of 163 residues 163 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ABL TYROSINE KINASE P00519 (57-218) (ABL1_HUMAN)search Homo sapienssearch < 90% 163 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00519 (57 - 218) ABL TYROSINE KINASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH3-domainsearch, SH2 domainsearch SH3 Domainssearch, SHC Adaptor Proteinsearch SH2 domainsearch, SH3 domainsearch
Chain InterPro annotation
A SH2 domainsearch SH3 domainsearch