2aa6 Summary


Mineralocorticoid Receptor S810L Mutant with Bound Progesterone

The structure was published by Bledsoe, R.K., Madauss, K.P., Holt, J.A., et al., Trump, R.P., Willson, T.M., and Williams, S.P., in 2005 in a paper entitled "A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mineralocorticoid receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mineralocorticoid receptor P08235 (712-984) (MCR_HUMAN)search Homo sapienssearch < 90% 275 94%
B Mineralocorticoid receptor P08235 (712-984) (MCR_HUMAN)search Homo sapienssearch < 90% 275 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08235 (712 - 984) Mineralocorticoid receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P08235) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch