› 2aa2

X-ray diffraction
1.95Å resolution

Mineralocorticoid Receptor with Bound Aldosterone

Released:
DOI: 10.2210/pdb2aa2/pdb
PDB entry 2aa2 coloured by chain, front view.
PDB entry 2aa2 coloured by chain, side view.
PDB entry 2aa2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor.
Bledsoe RK, Madauss KP, Holt JA, Apolito CJ, Lambert MH, Pearce KH, Stanley TB, Stewart EL, Trump RP, Willson TM, Williams SP
J Biol Chem 280 31283-93 (2005)
PMID: 15967794

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140040 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mineralocorticoid receptor Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 31.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08235 (Residues: 712-984; Coverage: 28%)
Gene names: MCR, MLR, NR3C2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

4 bound ligands:
Ligand BOG 1 x BOG
Ligand SO4 1 x SO4
Ligand AS4 1 x AS4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2221
Unit cell:
a: 92.617Å b: 173.139Å c: 42.166Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.235
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.
Huang et al. (2010)
24 more

33 mentions without citation

Emergence and evolution of the renin-angiotensin-aldosterone system.
Fournier et al. (2012)
32 more