2a84 Summary


Crystal structure of A Pantothenate synthetase complexed with ATP

The structure was published by Wang, S. and Eisenberg, D., in 2006 in a paper entitled "Crystal Structure of the Pantothenate Synthetase from Mycobacterium tuberculosis, Snapshots of the Enzyme in Action." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.55 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Pantoate--beta-alanine ligase. This molecule has the UniProt identifier P9WIL5 (PANC_MYCTU)search. The sample contained 300 residues which is 96% of the natural sequence. Out of 300 residues 277 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Pantoate--beta-alanine ligase P9WIL5 (3-300) (PANC_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 96% 300 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P9WIL5 (3 - 300) Pantoate--beta-alanine ligase Mycobacterium tuberculosis

Chain Structural classification (SCOP) Structural classification (CATH)
A (P9WIL5) Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)search HUPssearch, Pantoate--beta-alanine Ligase; Chain: A,domain 2search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P9WIL5) pantothenate biosynthetic processsearch growthsearch beta-alanine metabolic processsearch metal ion bindingsearch pantoate-beta-alanine ligase activitysearch manganese ion bindingsearch ATP bindingsearch magnesium ion bindingsearch ligase activitysearch nucleotide bindingsearch protein bindingsearch cytoplasmsearch

Chain InterPro annotation
A Pantoate-beta-alanine ligasesearch Rossmann-like alpha/beta/alpha sandwich foldsearch