2a5t

X-ray diffraction
2Å resolution

Crystal Structure Of The NR1/NR2A ligand-binding cores complex

Released:
Source organism: Rattus norvegicus
Primary publication:
Subunit arrangement and function in NMDA receptors.
Nature 438 185-92 (2005)
PMID: 16281028

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-152907 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor ionotropic, NMDA 1 Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.34 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P35439 (Residues: 394-800; Coverage: 32%)
Gene names: Grin1, Nmdar1
Sequence domains:
Structure domains: Periplasmic binding protein-like II
Glutamate receptor ionotropic, NMDA 2A Chain: B
Molecule details ›
Chain: B
Length: 284 amino acids
Theoretical weight: 31.85 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00959 (Residues: 401-802; Coverage: 20%)
Gene name: Grin2a
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 54.64Å b: 89.989Å c: 126.116Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.213 0.253
Expression system: Escherichia coli