2a4z Summary

pdbe.org/2a4z
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Crystal Structure of human PI3Kgamma complexed with AS604850

The structure was published by Camps, M., Ruckle, T., Ji, H., et al., Cirillo, R., Schwarz, M.K., and Rommel, C., in 2005 in a paper entitled "Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform. This molecule has the UniProt identifier P48736 (PK3CG_HUMAN)search. The sample contained 966 residues which is < 90% of the natural sequence. Out of 966 residues 773 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform P48736 (144-1102) (PK3CG_HUMAN)search Homo sapienssearch < 90% 966 84%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P48736 (144 - 1102) Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1search, C2- domain Calcium/lipid binding domainsearch, Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch, Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4search, Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 5search Phosphatidylinositol 3- and 4-kinasesearch, Phosphoinositide 3-kinase family, accessory domain (PIK domain)search, Phosphoinositide 3-kinase C2search, PI3-kinase family, ras-binding domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P48736) phosphatidylinositol-mediated signalingsearch phosphatidylinositol phosphorylationsearch phosphotransferase activity, alcohol group as acceptorsearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A C2 domainsearch Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domainsearch Phosphatidylinositol 3-/4-kinase, catalytic domainsearch Phosphoinositide 3-kinase, accessory (PIK) domainsearch Phosphatidylinositol 3-kinase, C2 domainsearch Protein kinase-like domainsearch Phosphatidylinositol Kinasesearch Armadillo-type foldsearch Phosphatidylinositol 3/4-kinase, conserved sitesearch Ubiquitin-related domainsearch