2a2k Summary

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Crystal Structure of an active site mutant, C473S, of Cdc25B Phosphatase Catalytic Domain

The structure was published by Sohn, J., Parks, J.M., Buhrman, G., et al., Edelsbrunner, H., Yang, W., and Rudolph, J., in 2005 in a paper entitled "Experimental Validation of the Docking Orientation of Cdc25 with Its Cdk2-CycA Protein Substrate." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.52 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of M-phase inducer phosphatase 2. This molecule has the UniProt identifier P30305 (MPIP2_HUMAN)search. The sample contained 175 residues which is < 90% of the natural sequence. Out of 175 residues 171 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A M-phase inducer phosphatase 2 P30305 (391-564) (MPIP2_HUMAN)search Homo sapienssearch < 90% 175 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P30305 (391 - 564) M-phase inducer phosphatase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Oxidized Rhodanese, domain 1search Rhodanese-like domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P30305) mitotic M phasesearch protein dephosphorylationsearch intracellularsearch protein tyrosine phosphatase activitysearch

Chain InterPro annotation
A M-phase inducer phosphatasesearch Rhodanese-like domainsearch