2a27 Summary

pdbe.org/2a27
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Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 8 monomers in the asymmetric unit

A publication describing this structure is not available. The depositing authors are Kursula, P.search; Lehmann, F.search; Shani, G.search; Kimchi, A.search; Wilmanns, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Death-associated protein kinase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Death-associated protein kinase 2 Q9UIK4 (11-330) (DAPK2_HUMAN)search Homo sapienssearch < 90% 321 94%
B Death-associated protein kinase 2 Q9UIK4 (11-330) (DAPK2_HUMAN)search Homo sapienssearch < 90% 321 94%
C Death-associated protein kinase 2 Q9UIK4 (11-330) (DAPK2_HUMAN)search Homo sapienssearch < 90% 321 94%
D Death-associated protein kinase 2 Q9UIK4 (11-330) (DAPK2_HUMAN)search Homo sapienssearch < 90% 321 94%
E Death-associated protein kinase 2 Q9UIK4 (11-330) (DAPK2_HUMAN)search Homo sapienssearch < 90% 321 94%
F Death-associated protein kinase 2 Q9UIK4 (11-330) (DAPK2_HUMAN)search Homo sapienssearch < 90% 321 94%
G Death-associated protein kinase 2 Q9UIK4 (11-330) (DAPK2_HUMAN)search Homo sapienssearch < 90% 321 94%
H Death-associated protein kinase 2 Q9UIK4 (11-330) (DAPK2_HUMAN)search Homo sapienssearch < 90% 321 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9UIK4 (11 - 330) Death-associated protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D, E, F, G, H (Q9UIK4) protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Myosin light chain kinase-relatedsearch