2a1a Summary

pdbe.org/2a1a
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PKR kinase domain-eIF2alpha Complex

The structure was published by Dar, A.C., Dever, T.E., and Sicheri, F., in 2005 in a paper entitled "Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Eukaryotic translation initiation factor 2 alpha subunit and Interferon-induced, double-stranded RNA-activated protein kinase.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Eukaryotic translation initiation factor 2 alpha subunit P20459 (4-176) (IF2A_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 175 92%
B Interferon-induced, double-stranded RNA-activated protein kinase P19525 (258-538) (E2AK2_HUMAN)search Homo sapienssearch < 90% 284 95%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P20459 (4 - 176) Eukaryotic translation initiation factor 2 alpha subunit Saccharomyces cerevisiae
P19525 (258 - 538) Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Nucleic acid-binding proteinssearch, Translation initiation factor 2; subunit 1; domain 2search S1 RNA binding domainsearch, Eukaryotic translation initiation factor 2 alpha subunitsearch
B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P20459) RNA bindingsearch translation initiation factor activitysearch eukaryotic translation initiation factor 2 complexsearch
B (P19525) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Ribosomal protein S1, RNA-binding domainsearch Translation initiation factor 2, alpha subunitsearch Nucleic acid-binding, OB-foldsearch RNA-binding domain, S1search Translation initiation factor 2, alpha subunit, middle domainsearch
B Protein kinase domainsearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch