2a11 Summary


Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis

The structure was published by Akey, D.L. and Berger, J.M., in 2005 in a paper entitled "Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Ribonuclease III. This molecule has the UniProt identifier P9WH03 (RNC_MYCTU)search. The sample contained 242 residues which is 100% of the natural sequence. Out of 242 residues 154 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ribonuclease III P9WH03 (1-240) (RNC_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 242 63%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P9WH03 (1 - 240) Ribonuclease III Mycobacterium tuberculosis

Chain Structural classification (CATH)
A (P9WH03) Ribonuclease iii, N-terminal Endonuclease Domain; Chain Asearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P9WH03) RNA bindingsearch nuclease activitysearch endonuclease activitysearch ribonuclease III activitysearch hydrolase activitysearch metal ion bindingsearch cytoplasmsearch rRNA processingsearch RNA processingsearch mRNA processingsearch tRNA processingsearch rRNA catabolic processsearch growthsearch nucleic acid phosphodiester bond hydrolysissearch RNA phosphodiester bond hydrolysissearch RNA phosphodiester bond hydrolysis, endonucleolyticsearch

Chain InterPro annotation
A Ribonuclease III domainsearch Ribonuclease IIIsearch Double-stranded RNA-binding domainsearch