2a0c Summary


Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor

The structure was published by Krystof, V., McNae, I.W., Walkinshaw, M.D., et al., Orsag, M., Havlicek, L., and Strnad, M., in 2005 in a paper entitled "Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 293 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
X Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
X (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
X (P24941) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch protein kinase activitysearch cyclin bindingsearch kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch metal ion bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch histone kinase activitysearch nucleotide bindingsearch protein phosphorylationsearch mitotic G1 DNA damage checkpointsearch positive regulation of DNA-dependent DNA replication initiationsearch cell divisionsearch DNA replicationsearch positive regulation of transcription, DNA-templatedsearch DNA repairsearch G2/M transition of mitotic cell cyclesearch cellular response to nitric oxidesearch regulation of gene silencingsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch phosphorylationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch blood coagulationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch positive regulation of cell proliferationsearch G1/S transition of mitotic cell cyclesearch meiotic cell cyclesearch cellular response to DNA damage stimulussearch mitotic nuclear divisionsearch potassium ion transportsearch mitotic cell cyclesearch Ras protein signal transductionsearch centrosome duplicationsearch histone phosphorylationsearch cell cyclesearch meiotic nuclear divisionsearch nucleoplasmsearch cytosolsearch centrosomesearch nucleussearch condensed chromosomesearch endosomesearch chromosome, telomeric regionsearch cyclin-dependent protein kinase holoenzyme complexsearch Y chromosomesearch Cajal bodysearch cytoskeletonsearch X chromosomesearch transcription factor complexsearch cytoplasmsearch

Chain InterPro annotation
X Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch