Function and Biology Details
Reaction catalysed:
Hydrolysis of proteins, including elastin. Preferential cleavage Val-|- > Ala-|-.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- WAP-type 'four-disulfide core' domain
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin domain
- Elafin-like superfamily
- Peptidase S1, PA clan, chymotrypsin-like fold
- Serine proteases, trypsin family, serine active site
- Serine proteases, trypsin family, histidine active site
- Peptidase S1, PA clan
Structure domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Neutrophil elastase and Antileukoproteinase (preferred)
PDBe Complex ID:
PDB-CPX-137308 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Neutrophil elastase
Molecule details ›
Chain: E
Length: 218 amino acids
Theoretical weight: 23.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 218 amino acids
Theoretical weight: 23.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P08246 (Residues: 30-247; Coverage: 91%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Antileukoproteinase
Molecule details ›
Chain: I
Length: 50 amino acids
Theoretical weight: 5.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: WAP-type (Whey Acidic Protein) 'four-disulfide core'
Structure domains: Elafin-like
Length: 50 amino acids
Theoretical weight: 5.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P03973 (Residues: 83-132; Coverage: 47%)
Sequence domains: WAP-type (Whey Acidic Protein) 'four-disulfide core'
Structure domains: Elafin-like
