› 2ys5

Solution NMR

Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of hALK

Released:
DOI: 10.2210/pdb2ys5/pdb
PDB entry 2ys5 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ys5 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ys5 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2.
Koshiba S, Li H, Motoda Y, Tomizawa T, Kasai T, Tochio N, Yabuki T, Harada T, Watanabe S, Tanaka A, Shirouzu M, Kigawa T, Yamamoto T, Yokoyama S
J Struct Funct Genomics 11 125-41 (2010)
PMID: 20454865

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128997 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fibroblast growth factor receptor substrate 3 Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16.33 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43559 (Residues: 8-146; Coverage: 28%)
Gene name: FRS3
Sequence domains: PTB domain (IRS-1 type)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
ALK tyrosine kinase receptor Chain: B
Molecule details ›
Chain: B
Length: 19 amino acids
Theoretical weight: 2.34 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UM73 (Residues: 1571-1589; Coverage: 1%)
Gene name: ALK

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

2 review citations

Applications of isothermal titration calorimetry in pure and applied research--survey of the literature from 2010.
Ghai et al. (2012)
1 more

1 mention without citation

SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.
Liu et al. (2012)