› 2yjr

X-ray diffraction
1.9Å resolution

Structure of F1174L Mutant Anaplastic Lymphoma Kinase

Released:
DOI: 10.2210/pdb2yjr/pdb
PDB entry 2yjr coloured by chain, front view.
PDB entry 2yjr coloured by chain, side view.
PDB entry 2yjr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: McTigue M, Deng Y, Liu W, Brooun A

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ALK tyrosine kinase receptor Chain: A
Molecule details ›
Chain: A
Length: 342 amino acids
Theoretical weight: 38.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UM73 (Residues: 1093-1411; Coverage: 20%)
Gene name: ALK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 51.439Å b: 56.906Å c: 102.201Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 0.281
Expression system: Spodoptera frugiperda

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