2yja

X-ray diffraction
1.82Å resolution

Stapled Peptides binding to Estrogen Receptor alpha.

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-136926 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
STAPLED PEPTIDE Chain: A
Molecule details ›
Chain: A
Length: 13 amino acids
Theoretical weight: 1.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
Estrogen receptor Chain: B
Molecule details ›
Chain: B
Length: 255 amino acids
Theoretical weight: 29.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 299-551; Coverage: 43%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2221
Unit cell:
a: 75.032Å b: 110.407Å c: 65.192Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.198 0.234
Expression systems:
  • Not provided
  • Escherichia coli