› 2y7q

X-ray diffraction
3.4Å resolution

THE HIGH-AFFINITY COMPLEX BETWEEN IGE AND ITS RECEPTOR FC EPSILON RI

Released:
DOI: 10.2210/pdb2y7q/pdb
PDB entry 2y7q coloured by chain, front view.
PDB entry 2y7q coloured by chain, side view.
PDB entry 2y7q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.
Holdom MD, Davies AM, Nettleship JE, Bagby SC, Dhaliwal B, Girardi E, Hunt J, Gould HJ, Beavil AJ, McDonnell JM, Owens RJ, Sutton BJ
Nat Struct Mol Biol 18 571-6 (2011)
PMID: 21516097

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134794 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
High affinity immunoglobulin epsilon receptor subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 188 amino acids
Theoretical weight: 21.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P12319 (Residues: 26-209; Coverage: 77%)
Gene names: FCE1A, FCER1A
Sequence domains:
Structure domains: Immunoglobulins
Immunoglobulin heavy constant epsilon Chains: B, D
Molecule details ›
Chains: B, D
Length: 327 amino acids
Theoretical weight: 36.35 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P01854 (Residues: 104-427; Coverage: 59%)
Gene name: IGHE
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 99.491Å b: 103.341Å c: 110.122Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.245 0.292
Expression systems:
  • Homo sapiens
  • Mus musculus

Quick links

Citations

19 review citations

Getting Syk: spleen tyrosine kinase as a therapeutic target.
Geahlen RL. (2014)
18 more

13 mentions without citation

Immunoglobulins or Antibodies: IMGT® Bridging Genes, Structures and Functions.
Lefranc et al. (2020)
12 more