› 2y2v

X-ray diffraction
2.45Å resolution

Nonaged form of Mouse Acetylcholinesterase inhibited by sarin-Update

Released:
DOI: 10.2210/pdb2y2v/pdb
PDB entry 2y2v coloured by chain, front view.
PDB entry 2y2v coloured by chain, side view.
PDB entry 2y2v coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Akfur C, Artursson E, Ekstrom F

Function and Biology Details

Reaction catalysed: 
Acetylcholine + H(2)O = choline + acetate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149440 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetylcholinesterase Chains: A, B
Molecule details ›
Chains: A, B
Length: 548 amino acids
Theoretical weight: 60.35 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P21836 (Residues: 32-574; Coverage: 93%)
Gene name: Ache
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase

Ligands and Environments

5 bound ligands:
Ligand NAG 3 x NAG
Ligand PEG 3 x PEG
Ligand ME2 2 x ME2
Ligand P15 1 x P15
Ligand ETX 1 x ETX
1 modified residue:
Ligand SGB 2 x SGB

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: P212121
Unit cell:
a: 79.488Å b: 111.643Å c: 227.026Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.185 0.224
Expression system: Homo sapiens

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