› 2xzp

X-ray diffraction
2.72Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187808 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulator of nonsense transcripts 1 Chain: A
Molecule details ›
Chain: A
Length: 623 amino acids
Theoretical weight: 70.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92900 (Residues: 295-925; Coverage: 55%)
Gene names: KIAA0221, RENT1, UPF1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand GOL 3 x GOL
Ligand MLI 2 x MLI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P213
Unit cell:
a: 146.12Å b: 146.12Å c: 146.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.214
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

54 review citations

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes.
Lykke-Andersen et al. (2015)
53 more

7 mentions without citation

A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.
Nicholson et al. (2014)
6 more