› 2xwc

X-ray diffraction
1.82Å resolution

Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution

Released:
DOI: 10.2210/pdb2xwc/pdb
PDB entry 2xwc coloured by chain, front view.
PDB entry 2xwc coloured by chain, side view.
PDB entry 2xwc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for ASPP2 recognition by the tumor suppressor p73.
Canning P, von Delft F, Bullock AN
J Mol Biol 423 515-27 (2012)
PMID: 22917970

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127442 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor protein p73 Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15350 (Residues: 112-311; Coverage: 31%)
Gene names: P73, TP73
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand TAM 1 x TAM
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P4332
Unit cell:
a: 110.37Å b: 110.37Å c: 110.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.228
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Restoring the tumour suppressive function of p53 as a parallel strategy in melanoma therapy.
Lu et al. (2014)
2 more

9 mentions without citation

Structure and apoptotic function of p73.
Yoon et al. (2015)
8 more