› 2xfu

X-ray diffraction
2.2Å resolution

Human monoamine oxidase B with tranylcypromine

Released:
DOI: 10.2210/pdb2xfu/pdb
PDB entry 2xfu coloured by chain, front view.
PDB entry 2xfu coloured by chain, side view.
PDB entry 2xfu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Potentiation of ligand binding through cooperative effects in monoamine oxidase B.
Bonivento D, Milczek EM, McDonald GR, Binda C, Holt A, Edmondson DE, Mattevi A
J Biol Chem 285 36849-56 (2010)
PMID: 20855894

Function and Biology Details

Reactions catalysed: 
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150973 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amine oxidase [flavin-containing] B Chains: A, B
Molecule details ›
Chains: A, B
Length: 519 amino acids
Theoretical weight: 58.71 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P27338 (Residues: 2-520; Coverage: 100%)
Gene name: MAOB
Sequence domains: Flavin containing amine oxidoreductase
Structure domains:

Ligands and Environments


Cofactor: Ligand FA8 2 x FA8
1 bound ligand:
Ligand 3PL 2 x 3PL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C222
Unit cell:
a: 130.609Å b: 222.551Å c: 86.201Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.188 0.239
Expression system: Komagataella pastoris

Quick links

Citations

13 review citations

Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: focus on modulation of CNS monoamine neurotransmitter release.
Finberg JP. (2014)
12 more

6 mentions without citation

Inhibitors of Protein Methyltransferases and Demethylases.
Kaniskan et al. (2018)
5 more