2x2u

X-ray diffraction
2Å resolution

First two Cadherin-like domains from Human RET

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-139854 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Extracellular cell-membrane anchored RET cadherin 120 kDa fragment Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 28.7 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P07949 (Residues: 29-270; Coverage: 22%)
Gene names: CDHF12, CDHR16, PTC, RET
Sequence domains:
Structure domains: Cadherins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P43212
Unit cell:
a: 86.074Å b: 86.074Å c: 110.475Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.181 0.228
Expression system: Cricetulus griseus