› 2wy0

X-ray diffraction
2.38Å resolution

Crystal structure of mouse angiotensinogen in the oxidised form with space group P6122

Released:
DOI: 10.2210/pdb2wy0/pdb
PDB entry 2wy0 coloured by chain, front view.
PDB entry 2wy0 coloured by chain, side view.
PDB entry 2wy0 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
A redox switch in angiotensinogen modulates angiotensin release.
Zhou A, Carrell RW, Murphy MP, Wei Z, Yan Y, Stanley PL, Stein PE, Broughton Pipkin F, Read RJ
Nature 468 108-11 (2010)
PMID: 20927107

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145962 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiotensinogen Chain: C
Molecule details ›
Chain: C
Length: 453 amino acids
Theoretical weight: 49.61 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11859 (Residues: 25-477; Coverage: 100%)
Gene names: Agt, Serpina8
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NA 4 x NA
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P6122
Unit cell:
a: 64.65Å b: 64.65Å c: 461.82Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.206 0.253
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

39 review citations

Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease.
Powe et al. (2011)
38 more

3 mentions without citation

A redox switch in angiotensinogen modulates angiotensin release.
Zhou et al. (2010)
2 more