› 2wqr

X-ray diffraction
1.9Å resolution

The high resolution crystal structure of IgE Fc

Released:
DOI: 10.2210/pdb2wqr/pdb
PDB entry 2wqr coloured by chain, front view.
PDB entry 2wqr coloured by chain, side view.
PDB entry 2wqr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.
Holdom MD, Davies AM, Nettleship JE, Bagby SC, Dhaliwal B, Girardi E, Hunt J, Gould HJ, Beavil AJ, McDonnell JM, Owens RJ, Sutton BJ
Nat Struct Mol Biol 18 571-6 (2011)
PMID: 21516097

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134791 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Immunoglobulin heavy constant epsilon Chains: A, B
Molecule details ›
Chains: A, B
Length: 323 amino acids
Theoretical weight: 35.93 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P01854 (Residues: 105-427; Coverage: 59%)
Gene name: IGHE
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
4 bound ligands:
Ligand SO4 4 x SO4
Ligand GOL 2 x GOL
Ligand TRS 1 x TRS
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21212
Unit cell:
a: 130.502Å b: 75.282Å c: 79.144Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.234
Expression system: Mus musculus

Quick links

Citations

20 review citations

Getting Syk: spleen tyrosine kinase as a therapeutic target.
Geahlen RL. (2014)
19 more

14 mentions without citation

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.
Holdom et al. (2011)
13 more