› 2wm8

X-ray diffraction
1.75Å resolution

Crystal structure of human magnesium-dependent phosphatase 1 of the haloacid dehalogenase superfamily (MGC5987)

Released:
DOI: 10.2210/pdb2wm8/pdb
PDB entry 2wm8 coloured by chain, front view.
PDB entry 2wm8 coloured by chain, side view.
PDB entry 2wm8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yue WW, Shafqat N, Pike ACW, Chaikuad A, Bray JE, Pilka EW, Burgess-Brown N, Hapka E, Filippakopoulos P, von Delft F, Arrowsmith C, Weigelt J, Edwards A, Bountra C, Oppermann U

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183209 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Magnesium-dependent phosphatase 1 Chain: A
Molecule details ›
Chain: A
Length: 187 amino acids
Theoretical weight: 21.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86V88 (Residues: 1-165; Coverage: 94%)
Gene name: MDP1
Sequence domains: Acid Phosphatase
Structure domains: HAD superfamily/HAD-like

Ligands and Environments

1 bound ligand:
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P43212
Unit cell:
a: 62.34Å b: 62.34Å c: 111.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.163 0.198
Expression system: Escherichia coli BL21(DE3)

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