› 2wh9

Solution NMR

Solution structure of GxTX-1E

Released:
DOI: 10.2210/pdb2wh9/pdb
PDB entry 2wh9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2wh9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2wh9 coloured by chain, ensemble of 20 models, top view.
Source organism: Chilobrachys guangxiensis
Primary publication:
Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels .
Lee S, Milescu M, Jung HH, Lee JY, Bae CH, Lee CW, Kim HH, Swartz KJ, Kim JI
Biochemistry 49 5134-42 (2010)
PMID: 20509680

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160915 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kappa-theraphotoxin-Pg1a Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 3.96 KDa
Source organism: Chilobrachys guangxiensis
Expression system: Not provided
UniProt:
  • Canonical: P84835 (Residues: 1-36; Coverage: 100%)
Sequence domains: Ion channel inhibitory toxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 47%
Refinement method: CYANA
Expression system: Not provided

Quick links

Citations

2 review citations

Oxidation of KCNB1 K(+) channels in central nervous system and beyond.
Sesti et al. (2014)
1 more

5 mentions without citation

Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif.
Smith et al. (2011)
4 more