› 2wcq

X-ray diffraction
1.9Å resolution

Crystal Structure of Tip-Alpha N34 (HP0596) from Helicobacter pylori at pH4

Released:
DOI: 10.2210/pdb2wcq/pdb
PDB entry 2wcq coloured by chain, front view.
PDB entry 2wcq coloured by chain, side view.
PDB entry 2wcq coloured by chain, top view.
Source organism: Helicobacter pylori
Primary publication:
Structures of the tumor necrosis factor alpha inducing protein Tipalpha: a novel virulence factor from Helicobacter pylori.
Tosi T, Cioci G, Jouravleva K, Dian C, Terradot L
FEBS Lett 583 1581-5 (2009)
PMID: 19401200

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127744 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor alpha-inducing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 159 amino acids
Theoretical weight: 18.23 KDa
Source organism: Helicobacter pylori
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O25318 (Residues: 34-192; Coverage: 83%)
Gene name: HP_0596
Sequence domains: TNF-alpha-Inducing protein of Helicobacter
Structure domains: Helicobacter TNF-alpha-Inducing protein

Ligands and Environments

1 bound ligand:
Ligand CIT 2 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 31.36Å b: 101.99Å c: 47.255Å
α: 90° β: 94.38° γ: 90°
R-values:
R R work R free
0.197 0.195 0.231
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Host genetic factors respond to pathogenic step-specific virulence factors of Helicobacter pylori in gastric carcinogenesis.
He et al. (2014)
3 more