› 2vz6

X-ray diffraction
2.3Å resolution

Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804

Released:
DOI: 10.2210/pdb2vz6/pdb
PDB entry 2vz6 coloured by chain, front view.
PDB entry 2vz6 coloured by chain, side view.
PDB entry 2vz6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S
PLoS Biol 8 e1000426 (2010)
PMID: 20668654

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194069 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type II subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 313 amino acids
Theoretical weight: 35.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UQM7 (Residues: 9-302; Coverage: 62%)
Gene names: CAMK2A, CAMKA, KIAA0968
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand FEF 2 x FEF
Ligand PGO 3 x PGO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 76.244Å b: 113.621Å c: 131.868Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.163 0.203
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

33 review citations

Mechanisms of CaMKII action in long-term potentiation.
Lisman et al. (2012)
32 more

22 mentions without citation

Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II.
Stratton et al. (2013)
21 more