2vxw

X-ray diffraction
1.7Å resolution

Structural and Functional Studies of the Potent Anti-HIV Chemokine Variant P2-RANTES

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146625 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RANTES(4-68) Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 69 amino acids
Theoretical weight: 7.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P13501 (Residues: 33-91; Coverage: 87%)
Gene names: CCL5, D17S136E, SCYA5
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 116.678Å b: 51.982Å c: 61.692Å
α: 90° β: 117.87° γ: 90°
R-values:
R R work R free
0.217 0.217 0.248
Expression system: Escherichia coli BL21(DE3)