› 2vn9

X-ray diffraction
2.3Å resolution

Crystal Structure of Human Calcium Calmodulin dependent Protein Kinase II delta isoform 1, CAMKD

Released:
DOI: 10.2210/pdb2vn9/pdb
PDB entry 2vn9 coloured by chain, front view.
PDB entry 2vn9 coloured by chain, side view.
PDB entry 2vn9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S
PLoS Biol 8 e1000426 (2010)
PMID: 20668654

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171757 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type II subunit delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 301 amino acids
Theoretical weight: 34.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13557 (Residues: 10-309; Coverage: 60%)
Gene names: CAMK2D, CAMKD
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand PO4 4 x PO4
Ligand CL 1 x CL
Ligand EPE 1 x EPE
Ligand GVD 2 x GVD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 68.276Å b: 68.276Å c: 313.45Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.211 0.248
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

33 review citations

Mechanisms of CaMKII action in long-term potentiation.
Lisman et al. (2012)
32 more

22 mentions without citation

CaMKII regulation in information processing and storage.
Coultrap et al. (2012)
21 more