› 2vlw

X-ray diffraction
1.39Å resolution

Crystal structure of the muscarinic toxin MT7 diiodoTYR51 derivative.

Released:
DOI: 10.2210/pdb2vlw/pdb
PDB entry 2vlw coloured by chain, front view.
PDB entry 2vlw coloured by chain, side view.
PDB entry 2vlw coloured by chain, top view.
Source organism: Dendroaspis angusticeps
Primary publication:
Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and N-methylscopolamine-occupied states.
Fruchart-Gaillard C, Mourier G, Marquer C, Stura E, Birdsall NJ, Servent D
Mol Pharmacol 74 1554-63 (2008)
PMID: 18784346

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185845 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Muscarinic toxin 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 65 amino acids
Theoretical weight: 7.74 KDa
Source organism: Dendroaspis angusticeps
Expression system: Not provided
UniProt:
  • Canonical: Q8QGR0 (Residues: 22-86; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

2 bound ligands:
Ligand ACT 1 x ACT
Ligand SO4 2 x SO4
1 modified residue:
Ligand TYI 2 x TYI

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 26.766Å b: 56.577Å c: 45.308Å
α: 90° β: 95.17° γ: 90°
R-values:
R R work R free
0.2 0.199 0.212
Expression system: Not provided

Quick links

Citations

3 review citations

Muscarinic toxins: tools for the study of the pharmacological and functional properties of muscarinic receptors.
Servent et al. (2009)
2 more

10 mentions without citation

Structural and Functional Diversity of Animal Toxins Interacting With GPCRs.
Van Baelen et al. (2022)
9 more