› 2v7o

X-ray diffraction
2.25Å resolution

Crystal structure of human calcium-calmodulin-dependent protein kinase II gamma

Released:
DOI: 10.2210/pdb2v7o/pdb
PDB entry 2v7o coloured by chain, front view.
PDB entry 2v7o coloured by chain, side view.
PDB entry 2v7o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S
PLoS Biol 8 e1000426 (2010)
PMID: 20668654

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171755 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type II subunit gamma Chain: A
Molecule details ›
Chain: A
Length: 336 amino acids
Theoretical weight: 38.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13555 (Residues: 3-315; Coverage: 56%)
Gene names: CAMK, CAMK-II, CAMK2G, CAMKG
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand DRN 1 x DRN
Ligand EDO 2 x EDO
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 84.703Å b: 117.226Å c: 75.968Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.176 0.241
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

35 review citations

Mechanisms of CaMKII action in long-term potentiation.
Lisman et al. (2012)
34 more

12 mentions without citation

Ca(2+)/calmodulin-dependent protein kinases.
Swulius et al. (2008)
11 more