› 2v70

X-ray diffraction
3.01Å resolution

Third LRR domain of human Slit2

Released:
DOI: 10.2210/pdb2v70/pdb
PDB entry 2v70 coloured by chain, front view.
PDB entry 2v70 coloured by chain, side view.
PDB entry 2v70 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3.
Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA
Acta Crystallogr D Biol Crystallogr 63 961-8 (2007)
PMID: 17704564

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131762 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Slit homolog 2 protein N-product Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 220 amino acids
Theoretical weight: 24.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O94813 (Residues: 502-716; Coverage: 14%)
Gene names: SLIL3, SLIT2
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 63.65Å b: 96.86Å c: 87.15Å
α: 90° β: 95.32° γ: 90°
R-values:
R R work R free
0.225 0.222 0.271
Expression system: Homo sapiens

Quick links

Citations

1 review citation

A roundabout way to cancer.
Ballard et al. (2012)
12 other articles

3 mentions without citation

Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.
Chao et al. (2010)
2 more