› 2uz8

X-ray diffraction
2Å resolution

The crystal structure of p18, human translation elongation factor 1 epsilon 1

Released:
DOI: 10.2210/pdb2uz8/pdb
PDB entry 2uz8 coloured by chain, front view.
PDB entry 2uz8 coloured by chain, side view.
PDB entry 2uz8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM.
Kim KJ, Park MC, Choi SJ, Oh YS, Choi EC, Cho HJ, Kim MH, Kim SH, Kim DW, Kim S, Kang BS
J Biol Chem 283 14032-40 (2008)
PMID: 18343821

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128901 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation elongation factor 1 epsilon-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 174 amino acids
Theoretical weight: 20.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43324 (Residues: 1-174; Coverage: 100%)
Gene names: AIMP3, EEF1E1, P18
Sequence domains: Glutathione S-transferase, C-terminal domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6C1
Spacegroup: C2221
Unit cell:
a: 46.336Å b: 77.915Å c: 194.784Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.245
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Aminoacyl tRNA synthetases and their connections to disease.
Park et al. (2008)
9 more

5 mentions without citation

Functional expansion of human tRNA synthetases achieved by structural inventions.
Guo et al. (2010)
4 more